Chokoloskee is an unincorporated community at the edge of the Ten Thousand Islands in Collier County, Florida, United States. The population was 359 at the 2010 census and it is part of the Naples–Marco Island Metropolitan Statistical Area. Inhabited by Native Americans for at least 1500 years before European explorers first recorded visiting the island, the current settlement can be traced back to 1874. Today, the isolated community's economy is largely based on boating and recreational boat fishing in the Ten Thousand Islands and the nearby Gulf of Mexico and ecotourism to nearby Everglades National Park.